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KMID : 1123920050190051386
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 5 p.1386 ~ p.1390
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Anti-inflammatory and Anti-allergic Effects of Lycii Fructus Extract
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Lee Young-Sun
Lee Geum-Hong
Kwon Young-Kyu
Lee In-Kyung
Xue Charlie-C.L.
Li Chun-G
Lee Se-Young
Shin Sang-Woo
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Abstract
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Lycii Fructus (LF) has been reported to possess various biological activities. In this study, we investigated the anti-inflammatory and anti-allergic effects of LF extract in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells and rat peritoneal mast cells(RPMC). LF extract inhibited NO production and the expressions of inducible NO synthase (iNOS) mRNA and enzyme protein, determined by Griess reactions, RT-PCR and Western blotting, respectively, in LPS-stimulated RAW 264.7 macrophages cells. LF extract significantly inhibited histamine release in compound48/80 stimulated rat peritoneal mast cells compared with the compound48/80 only treated cells. It is suggested that the LF extract can improve the inflammation status that involves the histamine release.
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KEYWORD
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Lycii Fructus, anti-allergic, anti-inflammatory, NO, Compound 48/80
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